Insilico discovery of novel Phosphodiesterase 4 (PDE4) inhibitors for the treatment of psoriasis: Insights from computer aided drug design approaches.

Psoriasis is chronic immune-mediated inflammatory disorder characterized by various comorbidities, erythematous plaques with silvery scale which can lead to psoriatic arthritis.The phosphodiesterase 4 (PDE4) protein is a potential drug target to control Psoriasis.In the current study, pharmacophore-based virtual screening of Diversity library of Ch

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Reasoned opinion on the review of the existing MRLs for carbofuran, carbosulfan, benfuracarb and furathiocarb and the setting of an import tolerance for carbofuran in cultivated mushrooms

In accordance with Article 43 of Regulation (EC) No 396/2005, the European Commission requested EFSA to evaluate the information provided by the European Spice Dog Harnesses Association (ESA) with a view to setting an import tolerance on cultivated mushrooms and considering in parallel, a review of all existing EU MRLs for the N-methyl-carbamate in

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Pulsatilla chinensis functions as a novel antihyperlipidemic agent by upregulating LDLR in an ERK-dependent manner

Abstract Background Pulsatilla chinensis (PC) is a traditional Chinese medicine (TCM) known for its beneficial activities.It has been historically used to treat dysentery, vaginal trichomoniasis, bacterial infections, and malignant tumors.The therapeutic potential of PC in the management of hypercholesterolemia remains largely unexplored.Methods A

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Defining and Regulating Peri-Urban Areas through a Landscape Planning Approach: The Case Study of Turin Metropolitan Area (Italy)

Peri-urbanization is a global phenomenon strongly linked to socio-demographic and settlement dynamics.Although peri-urbanization is a topic widely debated in academic literature, especially in the field of urban and regional planning, there is no Fo-Ti universal definition, and different types and interpretations of peri-urban areas can be found in

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